Lyrica 75 mg is an effective medication for managing fibromyalgia, a condition characterized by widespread musculoskeletal pain, fatigue, and sleep disturbances. The exact mechanism by which Lyrica provides relief in fibromyalgia is not entirely understood, but it primarily involves modulating neurotransmitter activity in the central nervous system.

Lyrica binds to the alpha-2-delta subunit of voltage-gated calcium channels in nerve cells. This binding reduces the release of excitatory neurotransmitters like glutamate, norepinephrine, and substance P, which play significant roles in pain transmission and perception. By dampening the activity of these neurotransmitters, Lyrica helps reduce the heightened pain sensitivity and abnormal pain processing associated with fibromyalgia.

Additionally, Lyrica enhances the action of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter that calms neuronal activity. This action helps alleviate not only pain but also anxiety and sleep disturbances commonly experienced by fibromyalgia patients.